Hck Products

Antibodies
Hck Antibody
Hck Antibody
H00003055-D01P
Species: Hu
Applications: WB, ELISA, ICC/IF, PLA
Host: Rabbit Polyclonal
Hck Antibody (394903)
Hck Antibody (394903)
MAB3915
Species: Hu, Mu
Applications: WB
Host: Rat Monoclonal
Hck Antibody (3D12E10)
Hck Antibody (3D12E10)
NBP1-47514
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Antibody Pairs
Hck Antibody Pair
Hck Antibody Pair
H00003055-AP11
Species: Hu
Applications: S-ELISA
Hck Antibody Pair
Hck Antibody Pair
H00003055-PW1
Species: Hu
Applications: WB, IP
Hck Antibody Pair
Hck Antibody Pair
H00003055-PW2
Species: Hu
Applications: WB, IP
Lysates
Hck Overexpression Lysate (De ...
Hck Overexpression Lysate (Denatured)
H00003055-T01
Species: Hu
Applications: WB
Hck Overexpression Lysate (Na ...
Hck Overexpression Lysate (Native)
NBP2-08146
Applications: WB
Proteins
Hck Partial Recombinant Prote ...
Hck Partial Recombinant Protein
H00003055-Q01
Species: Hu
Applications: WB, ELISA, PA
Hck Recombinant Protein
Hck Recombinant Protein
H00003055-P01
Species: Hu
Applications: WB, ELISA, PA
Hck Recombinant Protein
Hck Recombinant Protein
NBP1-99500
RNAi
Hck RNAi
Hck RNAi
H00003055-R02
Species: Hu

Description

The 60-kilodalton protein encoded by HCK resembles the product of the proto-oncogene c-src and is therefore likely to be a peripheral membrane protein (1). Protein-tyrosine kinase Hck is primarily expressed in hematopoietic cells, particularly granulocytes. Protein-tyrosine kinases are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes and as components of growth factor receptors (2). Tyrosine kinases of the Src family are regulated via their Src homology 2 (SH2) and SH3 domains. The Nef protein of human immunodeficiency virus-1 (HIV-1) has previously been shown to bind with high affinity and specificity in vitro to the SH3 domain of Hck, a Src family member expressed primarily in myeloid cells. Results provide direct evidence that SH3 engagement is sufficient to activate a Src family kinase in vivo and suggest that Hck may be activated by Nef in HIV-infected macrophages (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 3055
Alternate Names
  • EC 2.7.10.2
  • EC 2.7.10
  • p59-HCK/p60-HCK
  • tyrosine-protein kinase HCK
  • hemopoietic cell kinaseJTK9

Research Areas for Hck

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for Hck

Discover related pathways, diseases and genes to Hck. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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