HBG1/2 Products

Description

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Bioinformatics

Entrez	3047 Human 3048 Human
Uniprot	AAH10913 Human AAH10914 Human NM_000559 Human NP_000550 Human P69892 Human
Product By Gene ID	3047
Alternate Names	abnormal hemoglobin A-gamma globin gamma A hemoglobin gamma globin Gamma-1-globin gamma-2-globin gamma-globin chain G-gamma globin Paulinia Hb F Agamma hb F Ggamma HBGA HBGR HBG-T1 HBG-T2 Hemoglobin gamma-1 chain hemoglobin gamma-2 chain Hemoglobin gamma-A chain hemoglobin gamma-G chain hemoglobin subunit gamma-1 hemoglobin subunit gamma-2 hemoglobin, gamma A hemoglobin, gamma G hemoglobin, gamma, regulator of HSGGL1 methemoglobin PRO2979 TNCY