GTF3C2 Products

Description

General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.

Bioinformatics

Entrez	2976 Human
Uniprot	AAH20981 Human NM_001521 Human NP_001030598 Human NP_001030598.1 Human NP_001512.1 Human Q8WUA4 Human
Product By Gene ID	2976
Alternate Names	general transcription factor 3C polypeptide 2 general transcription factor IIIC, polypeptide 2, beta 110kDa KIAA0011general transcription factor IIIC, polypeptide 2 (beta subunit, 110kD) TF3C-beta TFIIIC 110 kDa subunit TFIIIC110Transcription factor IIIC 110 kDa subunit TFIIIC-BETA Transcription factor IIIC subunit beta