GPR78 Products

Antibodies
GPR78 Antibody
GPR78 Antibody
NBP1-86467
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
GPR78 Antibody
GPR78 Antibody
NLS443
Species: Hu
Applications: IHC-P
Host: Rabbit Polyclonal
Lysates
GPR78 Overexpression Lysate ( ...
GPR78 Overexpression Lysate (Native)
NBL1-11293
Applications: WB
Proteins
GPR78 Recombinant Protein
GPR78 Recombinant Protein
H00027201-P01
Species: Hu
Applications: WB, ELISA, PA
GPR78 Recombinant Protein Ant ...
GPR78 Recombinant Protein Antigen
NBP1-86467PEP
Species: Hu
Applications: AC
GPR78 Recombinant Protein
GPR78 Recombinant Protein
H00027201-G01
Species: Hu
RNAi
GPR78 RNAi
GPR78 RNAi
H00027201-R02
Species: Hu

Description

Within the ER misfolded proteins are detected by Bip(GPR78). In the presence of misfolded proteins, Bip disscociates from PERK, allowing it to homodimerize and autophosphoyate. In its dimerized, phosphorylated form PERK phosphorylates eIF2. The phosphorylation of eIF2 blocks the majority of translation to prevent the continued accumulation of protein in the ER. Bip also is binds to IRE1 and ATF6 under normal ER conditions, but dissociates upon accumulation of misfolded proteins. Unbound ATF6 is translocated to the gogli where it is converted into a cleaved, active form. The cleaved form of ATF6 is then able to up regulated transcription of UPR genes including XBP1. Activated IRE1 acts as an endoribonuclease to an intron from XBP1 transcripts. The XBP1 splice variant codes for an active transcription factor which activates transcription of P58IPK. P58IPK is a HSP40 protein which binds to and inhibits PERK. Thus, if the accumulated, misfolded proteins have been removed, P58IPK acts to shut down the UPR by removing the block to translation

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 27201
Alternate Names
  • G-protein coupled receptor 78
  • G protein-coupled receptor 78

Pathways for GPR78

View related products by pathway and learn more about each of the pathways below.

Cell Death
Senescence
Sensitization
Brain Development

Research Areas for GPR78

Find related products by research area and learn more about each of the different research areas below.

GPCR
Lipid and Metabolism
Unfolded Protein Response

PTMs for GPR78

Learn more about PTMs related to GPR78.

Phosphorylation
Cleavage
Ubiquitination

Bioinformatics Tool for GPR78

Discover related pathways, diseases and genes to GPR78. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related GPR78 Blog Posts

Check out the latest blog posts on GPR78.
GPR78 - an orphan receptor involved in psychiatric illness
G-protein coupled receptor 78 (GPR78) was identified based on homology to other GPCR family members. The GPR78 gene encodes an orphan receptor protein that is 363 amino acids in length and contains the typical seven transmembrane domain found in G...    Read more.
Read more GPR78 related blogs.