Species: Hu
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Description
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
Bioinformatics
Entrez |
Mouse Human Rat |
Uniprot |
Human Human Human Human |
Product By Gene ID |
2784 |
Alternate Names |
- G protein, beta-3 subunit
- GTP-binding regulatory protein beta-3 chain
- guanine nucleotide binding protein (G protein), beta polypeptide 3
- guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
- guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
- hypertension associated protein
- Transducin beta chain 3
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Research Areas for GNB3
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction