GNB3 Products

Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Bioinformatics

Entrez	2784 Human 14695 Mouse 60449 Rat
Uniprot	P16520 Human AAH02454 Human NP_002066.1 Human NM_002075 Human
Product By Gene ID	2784
Alternate Names	GTP-binding regulatory protein beta-3 chain hypertension associated protein G protein, beta-3 subunit guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Transducin beta chain 3 guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 guanine nucleotide binding protein (G protein), beta polypeptide 3

Diseases related to GNB3

Discover more about diseases related to GNB3.

Hypertensive Disease
Cholangiocarcinoma
Obesity
Essential Hypertension
Diabetes Mellitus
Cardiovascular Diseases
Infarction
Myocardial Infarction
Diabetes Mellitus, Non-insulin-dependent
Depressive Disorder
Coronary Artery Disease
Heart Diseases
Cerebrovascular Accident
Hypertrophy
Insulin Resistance
Left Ventricular Hypertrophy
Kidney Diseases
Coronary Heart Disease
Atherosclerosis

Pathways for GNB3

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Pathogenesis
Intracellular Signal Transduction
Vasoconstriction
Excretion
Transport
Chemotaxis
Vasodilation
Platelet Aggregation
Menopause
Cell Activation
Immune Response
Platelet Activation
Lymphocyte Chemotaxis
Response To Olanzapine
Cell Proliferation
Energy Homeostasis
Localization
Glomerular Filtration
Methylation
Cell Growth

Research Areas for GNB3

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Signal Transduction

PTMs for GNB3

Learn more about PTMs related to GNB3.

Methylation
Phosphorylation
Reduction
Amidation
Oxidation

Bioinformatics Tool for GNB3

Discover related pathways, diseases and genes to GNB3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.