GNB3 Products

Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Bioinformatics

Entrez	14695 Mouse 2784 Human 60449 Rat
Uniprot	AAH02454 Human NM_002075 Human NP_002066.1 Human P16520 Human
Product By Gene ID	2784
Alternate Names	G protein, beta-3 subunit GTP-binding regulatory protein beta-3 chain guanine nucleotide binding protein (G protein), beta polypeptide 3 guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 hypertension associated protein Transducin beta chain 3

Research Areas for GNB3

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Signal Transduction