GLE1 Products

Description

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunofluorescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	2733 Human
Uniprot	AAH30012 Human
Product By Gene ID	2733
Alternate Names	GLE1 (yeast homolog)-like, RNA export mediator GLE1 RNA export mediator homolog (yeast) GLE1LGLE1 RNA export mediator-like (yeast) GLE1-like protein GLE1-like, RNA export mediator hGLE1GLE1 RNA export mediator (yeast) LCCS LCCS1 lethal congenital contracture syndrome 1 nucleoporin GLE1