GLE1 Products

Description

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunofluorescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	2733 Human
Uniprot	AAH30012 Human AAH30012.1 Human NP_001003722 Human NP_001003722.1 Human Q53GS7 Human
Product By Gene ID	2733
Alternate Names	GLE1 (yeast homolog)-like, RNA export mediator GLE1 RNA export mediator homolog (yeast) GLE1LGLE1 RNA export mediator-like (yeast) GLE1-like protein GLE1-like, RNA export mediator hGLE1GLE1 RNA export mediator (yeast) LCCS LCCS1 lethal congenital contracture syndrome 1 nucleoporin GLE1