Gemin 3 Products

Antibodies
Gemin 3 Antibody
Gemin 3 Antibody
NBP1-84058
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Gemin 3 Antibody
Gemin 3 Antibody
NB100-1801
Species: Hu, Equine, Primate, Porcine, Squirrel
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Gemin 3 Antibody
Gemin 3 Antibody
H00011218-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Lysates
Gemin 3 Overexpression Lysate ...
Gemin 3 Overexpression Lysate (Den...
H00011218-T01
Species: Hu
Applications: WB
Gemin 3 Overexpression Lysate ...
Gemin 3 Overexpression Lysate (Nat...
NBL1-09786
Applications: WB
Proteins
Gemin 3 Recombinant Protein
Gemin 3 Recombinant Protein
H00011218-P02
Species: Hu
Applications: WB, ELISA, PA
Gemin 3 Recombinant Protein
Gemin 3 Recombinant Protein
H00011218-P01
Species: Hu
Applications: WB, ELISA, PA
Gemin 3 Partial Recombinant P ...
Gemin 3 Partial Recombinant Protein
H00011218-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Gemin 3 RNAi
Gemin 3 RNAi
H00011218-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The survival of motor neurons (SMN) gene is the disease gene of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The SMN protein is part of a complex containing several proteins, of which one, SIP1 (SMN interacting protein 1), has been characterized so far. The SMN complex is found in both the cytoplasm and in the nucleus, where it is concentrated in bodies called gems. In the cytoplasm, SMN and SIP1 interact with the Sm core proteins of spliceosomal small nuclear ribonucleoproteins (snRNPs), and they play a critical role in snRNP assembly. In the nucleus, SMN is required for pre-mRNA splicing, likely by serving in the regeneration of snRNPs. A DEAD box putative RNA helicase, named Gemin 3 which is another component of the SMN complex, has been identified. Gemin 3 interacts directly with SMN, as well as with SmB, SmD2 and SmD3. Immunolocalization studies using mAbs to Gemin 3 show that it colocalizes with SMN in gems. Gemin 3 binds SMN via its unique COOH-terminal domain, and SMN mutations found in some SMA patients strongly reduce this interaction. The presence of a DEAD box motif in Gemin 3 suggests that it may provide the catalytic activity that plays a critical role in the function of the SMN complex on RNPs.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 11218
Alternate Names
  • Gemin-3
  • DEAD box protein DP 103
  • EC 3.6.4.13
  • DEAD box protein 20
  • SMN-interacting protein
  • Component of gems 3
  • probable ATP-dependent RNA helicase DDX20
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
  • GEMIN3gemin-3
  • DP103DEAD-box protein DP103
  • DKFZp434H052
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Research Areas for Gemin 3

Find related products by research area and learn more about each of the different research areas below.

Neuroscience

PTMs for Gemin 3

Learn more about PTMs related to Gemin 3.

Sumoylation
Phosphorylation
Methylation

Bioinformatics Tool for Gemin 3

Discover related pathways, diseases and genes to Gemin 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.