GAB1 Products

Antibodies
GAB1 Antibody (1A7)
GAB1 Antibody (1A7)
NBP2-37742
Species: Hu
Applications: WB, ELISA, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
GAB1 Overexpression Lysate (D ...
GAB1 Overexpression Lysate (Denatu...
H00002549-T01
Species: Hu
Applications: WB
GAB1 Overexpression Lysate (N ...
GAB1 Overexpression Lysate (Native)
NBL1-10904
Applications: WB
GAB1 Overexpression Lysate (N ...
GAB1 Overexpression Lysate (Native)
NBL1-10903
Applications: WB
Proteins
GAB1 Recombinant Protein
GAB1 Recombinant Protein
H00002549-P01
Species: Hu
Applications: WB, ELISA, PA
GAB1 Partial Recombinant Prot ...
GAB1 Partial Recombinant Protein
H00002549-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
GAB1 RNAi
GAB1 RNAi
H00002549-R01
Species: Hu
GAB1 RNAi
GAB1 RNAi
H00002549-R02
Species: Hu

Description

Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 2549
Alternate Names
  • GRB2-associated-binding protein 1
  • GRB2-associated binder 1
  • Growth factor receptor bound protein 2-associated protein 1
  • GRB2-associated binding protein 1

Research Areas for GAB1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for GAB1

Discover related pathways, diseases and genes to GAB1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related GAB1 Blog Posts

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