FXYD2 Products

Antibodies
FXYD2 Antibody (1C3-B3)
FXYD2 Antibody (1C3-B3)
H00000486-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
FXYD2 Antibody
FXYD2 Antibody
NBP2-49574
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Lysates
FXYD2 Overexpression Lysate ( ...
FXYD2 Overexpression Lysate (Native)
NBL1-10877
Applications: WB
FXYD2 Overexpression Lysate ( ...
FXYD2 Overexpression Lysate (Native)
NBP2-09449
Applications: WB
FXYD2 Overexpression Lysate ( ...
FXYD2 Overexpression Lysate (Native)
NBL1-10878
Applications: WB
Proteins
FXYD2 Recombinant Protein
FXYD2 Recombinant Protein
H00000486-P01
Species: Hu
Applications: WB, ELISA, PA
FXYD2 Recombinant Protein Ant ...
FXYD2 Recombinant Protein Antigen
NBP2-49574PEP
Species: Hu
Applications: AC
RNAi
FXYD2 RNAi
FXYD2 RNAi
H00000486-R04
Species: Hu
Applications: RNAi, RNAi SP
FXYD2 RNAi
FXYD2 RNAi
H00000486-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

FXYD2 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 486
Alternate Names
  • FXYD domain-containing ion transport regulator 2
  • HOMG2
  • ATP1C
  • Na(+)/K(+) ATPase subunit gamma
  • sodium/potassium-transporting ATPase subunit gamma
  • Sodium pump gamma chain
  • Sodium-potassium-ATPase, gamma polypeptide
  • MGC12372
  • ATP1G1ATPase, Na+/K+ transporting, gamma 1 polypeptide
  • hypomagnesemia 2, renal
  • FXYD domain containing ion transport regulator 2

PTMs for FXYD2

Learn more about PTMs related to FXYD2.

Phosphorylation
Glycosylation
Cleavage
Dephosphorylation

Bioinformatics Tool for FXYD2

Discover related pathways, diseases and genes to FXYD2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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