FUBP3 Products

Description

Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxylterminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.

Bioinformatics

Entrez	8939 Human
Uniprot	Q96I24 Human AAH07874.1 Human
Product By Gene ID	8939
Alternate Names	far upstream element-binding protein 3 FLJ25229 FUSE-binding protein 3 FBP3 far upstream element (FUSE) binding protein 3

Diseases related to FUBP3

Discover more about diseases related to FUBP3.

Neoplasms
Carcinoma
Malignant Neoplasms
Bladder Neoplasm
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Cerebellar Neoplasms
Liver Carcinoma
Malignant Neoplasm Of Liver
Kidney Neoplasm
Hepatocarcinogenesis
Malignant Neoplasm Of Urinary Bladder
Carcinogenesis
Prostatic Neoplasms
Renal Cell Carcinoma
Liver Neoplasms
Medulloblastoma
Genitourinary Neoplasms

Pathways for FUBP3

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
Translation
Single-stranded Dna Binding
Localization
Rna Interference

Bioinformatics Tool for FUBP3

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