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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq]
![Western Blot Frizzled-7 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Frizzled7_AF198_Western_Blot_17624.jpg)
![Immunohistochemistry Frizzled-7 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Frizzled-7_AF198_Immunohistochemistry_6723.jpg)
![Western Blot Frizzled-7 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af198_mouse-frizzled-7-affinity-purified-polyclonal-ab-8120255541725.jpg)
