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FMO4, also known as Dimethylaniline monooxygenase [N-oxide-forming] 4 or Flavin containing monooxygenase 4, is a 558 amino acid protein that is 63 kDa, most commonly found in liver tissue with microsome membrane and endoplasmic reticulum membrane subcellular location, and is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Current research is being performed on several diseases and disorders including trimethylaminuria, hepatitis, prader-willi syndrome, plasma cell neoplasm, and hearing loss. This protein has been shown to have interactions with CYP3A5, CYP3A4, CYP3A7, CYP2D6 and CYP3A43 in xenobiotic metabolic and oxidation-reduction pathways.
