FLASH Products

Description

A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2).

Bioinformatics

Entrez	9994 Human
Product By Gene ID	9994
Alternate Names	CASP8 associated protein 2 caspase 8 associated protein 2 CED-4 FLASHKIAA1315CASP8-associated protein 2 FLICE associated huge FLICE-associated huge protein FLJ11208 human FLASH RIP25FLASH homolog RIP25

Research Areas for FLASH

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors