Fgr Products

Description

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Bioinformatics

Entrez	2268 Human
Uniprot	NP_005239.1 Human
Product By Gene ID	2268
Alternate Names	c-fgr c-src-2 proto-oncogene c-src2 EC 2.7.10 EC 2.7.10.2 Fgr FLJ43153 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog MGC75096 p55-c-fgr protein p55c-fgr p55-Fgr p58c-fgr Proto-oncogene c-Fgr proto-oncogene tyrosine-protein kinase FGR Src2 SRC2c-fgr protooncogene tyrosine-protein kinase Fgr

Research Areas for Fgr

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Protein Kinase