FBXW5 Products

Description

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq]

Bioinformatics

Entrez	54461 Human
Uniprot	AAH00850.1 Human
Product By Gene ID	54461
Alternate Names	DKFZp434B205 F-box and WD repeat domain containing 5 F-box and WD-40 domain protein 5 F-box and WD-40 domain-containing protein 5 F-box/WD repeat-containing protein 5 Fbw5 MGC20962 RP11-229P13.10 WD repeat-containing F-box protein FBW5

Research Areas for FBXW5

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Cell Biology
Cell Cycle and Replication