ERP29 Products

Description

Proper protein folding and post-translational modifications are essential for secretory protein export out of the endoplasmic reticulum. This task is accomplished by chaperone proteins such as protein disulfide isomerase (PDI), GRP94, and BiP. A recently characterized protein, designated ERp29, is closely related to these chaperone proteins and appears to be upregulated during ER stress conditions. ERp29 is a soluble 259-residue protein that is localized to the lumen of the endoplasmic reticulum in all mammalian cells. Research has shown that there are two primary domains within ERp29. The first is the C-terminal region that is a novel, all helical, fold that is most likely involved with ERp29 retention to the ER. The second is the N-terminal region that resembles that of PDI's thioredoxin module. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER.

Bioinformatics

Entrez	10961 Human 67397 Mouse 117030 Rat
Uniprot	P30040 Human
Product By Gene ID	10961
Alternate Names	C12orf8chromosome 12 open reading frame 8 endoplasmic reticulum lumenal protein ERp28 endoplasmic reticulum protein 29 Endoplasmic reticulum resident protein 28 endoplasmic reticulum resident protein 29 ERp28Endoplasmic reticulum resident protein 31 ERp29 ERp31ERP28 PDIA9 PDI-DB protein disulfide isomerase family A, member 9

Research Areas for ERP29

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Membrane Trafficking and Chaperones
Stem Cell Markers