Endosialin/CD248/TEM1 Products

Description

Using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM1 was predicted to encode a type I transmembrane protein of 757 amino acids. The majority (685 amino acids) of the sequence was predicted to be extracellular, with only a short COOH-terminal cytoplasmic tail. A homology search revealed that the extracellular region of TEM1 has three EGF-like domains, as well as a C-lectin-like carbohydrate recognition domain with similarity to thrombomodulin.

Bioinformatics

Entrez	57124 Human
Product By Gene ID	57124
Alternate Names	2610111G01Rik CD164 sialomucin-like 1 CD164L1 CD248 antigen CD248 antigen, endosialin CD248 molecule, endosialin CD248 Endosialin MGC119479 TEM1 TEM1MGC119478 Tumor endothelial marker 1

Research Areas for Endosialin/CD248/TEM1

Find related products by research area and learn more about each of the different research areas below.

Cancer