Endo G Products

Description

The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndooG also cleaves DNA in vitro (4).

Bioinformatics

Entrez	2021 Human 362100 Rat
Uniprot	AAH04922 Human AAH04922.1 Human NM_004435 Human NP_004426 Human Q14249 Human
Product By Gene ID	2021
Alternate Names	EC 3.1.30.- Endo G endonuclease G endonuclease G, mitochondrial FLJ27463 mitochondrial endonuclease G

Research Areas for Endo G

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Hypoxia