Endo G Products

Antibodies
Endo G Antibody (5F1)
Endo G Antibody (5F1)
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Endo G Antibody
Endo G Antibody
NBP1-76657
Species: Hu, Mu, Rt, Ca
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Endo G Antibody
Endo G Antibody
NB120-10522
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Endo G Overexpression Lysate ...
Endo G Overexpression Lysate (Native)
NBL1-10264
Applications: WB
Endo G Overexpression Lysate ...
Endo G Overexpression Lysate (Dena...
H00002021-T01
Applications: WB
Proteins
Endo G Recombinant Protein
Endo G Recombinant Protein
H00002021-P01
Species: Hu
Applications: WB, ELISA, PA
Endo G Recombinant Protein An ...
Endo G Recombinant Protein Antigen
NBP1-86011PEP
Species: Hu
Applications: AC
Endo G Recombinant Protein An ...
Endo G Recombinant Protein Antigen
NBP1-87554PEP
Species: Hu
Applications: AC
RNAi
Endo G RNAi
Endo G RNAi
H00002021-R01
Species: Hu

Description

The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndooG also cleaves DNA in vitro (4).

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2021
Alternate Names
  • EC 3.1.30.-
  • mitochondrial endonuclease G
  • endonuclease G, mitochondrial
  • FLJ27463
  • Endo G
  • endonuclease G

Research Areas for Endo G

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Hypoxia

Bioinformatics Tool for Endo G

Discover related pathways, diseases and genes to Endo G. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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