ENC1 Products

Description

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]

Bioinformatics

Entrez	8507 Human
Uniprot	NM_003633 Human NP_003624 Human NP_003624.1 Human O14682 Human
Product By Gene ID	8507
Alternate Names	CCL28 ectodermal-neural cortex 1 (with BTB-like domain) ENC-1BTB domain-like (brain) FLJ39259 PIG10KLHL35 tumor protein p53 inducible protein 10

Research Areas for ENC1

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Neuroscience