Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, KD
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Po, Bv, Ca, ChHa, Eq, Fe, Gp, Ma-Op, Pm, Am, Ch, Pm, Pm, Pm-Or, Rb, RM
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: PAGE, Bioactivity
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: PAGE
Description
EMAP II (Endothelial-Monocyte-Activating Polypeptide II) is a proinflammatory cytokine and chemoattractant of macrophages and polymorphonuclear lymphocytes. EMAP II is synthesized as a 34 kDa precursor molecule which is cleaved to a biologically active 22 kDa mature polypeptide. This active protein is known to induce the procoagulant protein tissue factor on the surface of endothelial cells and modulate other properties of endothelial cells and monocytes in vitro, including the stimulation of TNF-alpha and myeloperoxidase. EMAP II activates neutrophils in vivo and induces an inflammatory reaction and tumor regression. EMAP II induces apoptosis in proliferating endothelial cells and inhibits neovascularization. This anti-angiogenic property is of interest to tumor biology. EMAP II is also a negative modulator of lung vascular growth.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
9255 |
| Alternate Names |
- aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
- EMAP-2
- EMAPIImember 1 (endothelialmonocyte-activating)
- endothelial-monocyte activating polypeptide II
- Multisynthase complex auxiliary component p43
- multisynthetase complex auxiliary component p43
|
![Western Blot EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/fullsize2/EMAPII_MAB1910_Western_Blot_20594.jpg)
![Immunocytochemistry EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/fullsize2/EMAPII_MAB1910_Immunocytochemistry__Immunofluorescence_20583.jpg)
![Immunohistochemistry EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/fullsize2/EMAPII_MAB1910_Immunohistochemistry_20671.jpg)
