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HAF018). A specific band was detected for EMAP-II at approximately 37 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox" target="_blank">
VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cancer cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
EMAP II (Endothelial-Monocyte-Activating Polypeptide II) is a proinflammatory cytokine and chemoattractant of macrophages and polymorphonuclear lymphocytes. EMAP II is synthesized as a 34 kDa precursor molecule which is cleaved to a biologically active 22 kDa mature polypeptide. This active protein is known to induce the procoagulant protein tissue factor on the surface of endothelial cells and modulate other properties of endothelial cells and monocytes in vitro, including the stimulation of TNF-alpha and myeloperoxidase. EMAP II activates neutrophils in vivo and induces an inflammatory reaction and tumor regression. EMAP II induces apoptosis in proliferating endothelial cells and inhibits neovascularization. This anti-angiogenic property is of interest to tumor biology. EMAP II is also a negative modulator of lung vascular growth.
![Western Blot EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/images/antibody/EMAPII_MAB1910_Western_Blot_20594.jpg)
![Immunocytochemistry EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/images/antibody/EMAPII_MAB1910_Immunocytochemistry__Immunofluorescence_20583.jpg)
![Immunohistochemistry EMAP-II/AIMP1 Antibody (959516) [Unconjugated]](http://images.novusbio.com/images/antibody/EMAPII_MAB1910_Immunohistochemistry_20671.jpg)
