E4F1 Products

Description

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.

Bioinformatics

Entrez	1877 Human
Uniprot	Q66K89 Human AAH80524.1 Human NP_004415 Human NP_004415.2 Human
Product By Gene ID	1877
Alternate Names	p120E4F EC 6.3.2.- Transcription factor E4F transcription factor E4F1 Putative E3 ubiquitin-protein ligase E4F1 E4FMGC99614 E4F transcription factor 1p50E4F

Diseases related to E4F1

Discover more about diseases related to E4F1.

Neoplasms
Cell Transformation, Neoplastic
Growth Arrest
Sarcoma
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Mammary Neoplasms
Histiocytic Sarcoma
Leukemia
Hyperplasia
Cholangiocarcinoma
Neurodegenerative Disorders
Ataxia
Dysplasia
Malignant Neoplasms
Exhaustion
Lymphoma
Neuroblastoma
Congenital Absence
Congenital Abnormality

Pathways for E4F1

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Cell Death
Cell Proliferation
Autophagic Cell Death
Osteoblast Differentiation
Mitosis
Stem Cell Maintenance
Proteolysis
M Phase
Keratinocyte Differentiation
Cell Cycle Arrest
Pronephros Formation
Cell Growth
Regulation Of Mrna Stability
Rna Interference

PTMs for E4F1

Learn more about PTMs related to E4F1.

Phosphorylation
Acetylation
Ubiquitination

Bioinformatics Tool for E4F1

Discover related pathways, diseases and genes to E4F1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.