E2F3 Products

Description

E2F3 is encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Bioinformatics

Entrez	1871 Human
Uniprot	AAH16847 Human CAH18140 Human NM_001949 Human NP_001940 Human O00716 Human
Product By Gene ID	1871
Alternate Names	DKFZp686C18211 E2F transcription factor 3 E2F-3 KIAA0075 MGC104598 transcription factor E2F3

Research Areas for E2F3

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
Stem Cell Markers