E2F-1 Products

E2F-1 Overexpression Lysate
E2F-1 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human E2F-1 Prote ...
Recombinant Human E2F-1 Protein
Species: Hu
Applications: WB, ELISA, PA, AP
E2F-1 Recombinant Protein Ant ...
E2F-1 Recombinant Protein Antigen
Species: Hu
Applications: AC
E2F-1 Recombinant Protein Ant ...
E2F-1 Recombinant Protein Antigen
Species: Hu
Applications: AC


E2F1 is encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.


Entrez Human
Uniprot Human
Product By Gene ID 1869
Alternate Names
  • transcription factor E2F1
  • PBR3
  • RBAP1
  • E2F-1
  • PRB-binding protein E2F-1
  • Retinoblastoma-binding protein 3
  • RBBP3
  • Retinoblastoma-associated protein 1
  • RBBP-3
  • RBP3
  • RBAP-1
  • E2F transcription factor 1

Research Areas for E2F-1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Transcription Factors and Regulators

Bioinformatics Tool for E2F-1

Discover related pathways, diseases and genes to E2F-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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