Dystonin Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	667
Alternate Names	230 kDa bullous pemphigoid antigen BP240 BPAFLJ30627 BPAG1FLJ32235 Bullous pemphigoid antigen 1 bullous pemphigoid antigen 1, 230/240kDa Bullous pemphigoid antigen CATX-15 D6S1101 DKFZp564B2416 DMHCATX15 DT Dystonia musculorum protein dystonin FLJ13425 FLJ21489 FLJ46791 Hemidesmosomal plaque protein KIAA0465 KIAA0728 KIAA1470 MACF2 trabeculin-beta

Research Areas for Dystonin

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