DUSP5 Products

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]

Bioinformatics

Entrez	1847 Human
Uniprot	NM_004419 Human NP_004410 Human
Product By Gene ID	1847
Alternate Names	dual specificity phosphatase 5 dual specificity protein phosphatase 5 Dual specificity protein phosphatase hVH3 DUSP EC 3.1.3.16 EC 3.1.3.48 HVH3VH1-like phosphatase 3 serine/threonine specific protein phosphatase VH3

Research Areas for DUSP5

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Protein Phosphatase