DPH4 Products

Description

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2.Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 CD685768.1 19-28 11-652 AL833128.1 1-642 653-3000 AC108456.7 42515-44862

Bioinformatics

Uniprot	Q6P3W2 Human
Product By Gene ID	120526
Alternate Names	CSL-type zinc finger-containing protein 3 DnaJ (Hsp40) homolog, subfamily C, member 24 dnaJ homolog subfamily C member 24 DPH4 homolog DPH4, JJJ3 homolog (S. cerevisiae) DPH4, JJJ3 homolog DPH41700030A21Rik JJJ3 S. cerevisiae) ZCSL3 zinc finger, CSL domain containing 3 zinc finger, CSL-type containing 3

Research Areas for DPH4

Find related products by research area and learn more about each of the different research areas below.

Amino Acids, Drugs and other small molecules
Cancer
Signal Transduction