DOK1 Products

Description

Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.

Bioinformatics

Entrez	1796 Human 312477 Rat
Uniprot	AAC51127 Human NM_001381 Human NP_001372 Human NP_001372.1 Human Q99704 Human
Product By Gene ID	1796
Alternate Names	docking protein 1 (downstream of tyrosine kinase 1) docking protein 1 docking protein 1, 62kD (downstream of tyrosine kinase 1) docking protein 1, 62kDa (downstream of tyrosine kinase 1) Downstream of tyrosine kinase 1 MGC117395 MGC138860 p62(dok) p62dok P62DOK pp62

Diseases related to DOK1

Discover more about diseases related to DOK1.

Neoplasms
Leukemia
Malignant Neoplasms
Tissue Adhesions
Myeloid Leukemia, Chronic
Myeloid Leukemia
Cell Transformation, Neoplastic
Metaplastic Cell Transformation
Lymphoid Leukemia
Nervousness
Chronic Lymphocytic Leukemia
Autoimmunity
Burkitt Lymphoma
Lymphoma
Endocrine Gland Neoplasms
Leukemogenesis
Hyperplasia
Multiple Endocrine Neoplasia
Malignant Neoplasm Of Thyroid
Carcinoma

Pathways for DOK1

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Cell Proliferation
Localization
Cell Activation
Cell Migration
Mitosis
Cell Adhesion
Pathogenesis
Methylation
Cytokine Production
Secretion
T Cell Activation
Cell Motility
Dna Methylation
Cell Cycle
Cell Growth
Mast Cell Activation
Integrin Activation
Lymphocyte Activation
Hyperphosphorylation
Immune Response

Research Areas for DOK1

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Phospho-Specific
Signal Transduction

PTMs for DOK1

Learn more about PTMs related to DOK1.

Phosphorylation
Methylation
Acetylation
Demethylation
Reduction
Dephosphorylation

Bioinformatics Tool for DOK1

Discover related pathways, diseases and genes to DOK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.