DOK1 Products

Antibodies
DOK1 [p Tyr362] Antibody
DOK1 [p Tyr362] Antibody
NB100-82112
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
DOK1 Antibody
DOK1 Antibody
NBP1-77064
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
DOK1 Antibody
DOK1 Antibody
NBP1-19886
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
DOK1 Antibody Pair
DOK1 Antibody Pair
H00001796-PW1
Species: Hu
Applications: WB, IP
Lysates
DOK1 Overexpression Lysate (D ...
DOK1 Overexpression Lysate (Denatu...
H00001796-T01
Species: Hu
Applications: WB
DOK1 Overexpression Lysate (N ...
DOK1 Overexpression Lysate (Native)
NBL1-09977
Applications: WB
Proteins
DOK1 Recombinant Protein
DOK1 Recombinant Protein
H00001796-P01
Species: Hu
Applications: WB, ELISA, PA
DOK1 Peptide
DOK1 Peptide
NBP1-77064PEP
Species: Hu
Applications: AC

Description

Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 1796
Alternate Names
  • p62dok
  • docking protein 1 (downstream of tyrosine kinase 1)
  • docking protein 1, 62kD (downstream of tyrosine kinase 1)
  • docking protein 1
  • pp62
  • P62DOK
  • p62(dok)
  • MGC138860
  • Downstream of tyrosine kinase 1
  • MGC117395
  • docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Research Areas for DOK1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

PTMs for DOK1

Learn more about PTMs related to DOK1.

Phosphorylation
Methylation
Acetylation
Demethylation
Reduction
Dephosphorylation

Bioinformatics Tool for DOK1

Discover related pathways, diseases and genes to DOK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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