Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
Bioinformatics
| Entrez |
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
1796 |
| Alternate Names |
- docking protein 1 (downstream of tyrosine kinase 1)
- docking protein 1
- docking protein 1, 62kD (downstream of tyrosine kinase 1)
- docking protein 1, 62kDa (downstream of tyrosine kinase 1)
- Downstream of tyrosine kinase 1
- MGC117395
- MGC138860
- p62(dok)
- p62dok
- P62DOK
- pp62
|
![Western Blot DOK1 [p Tyr362] Antibody - BSA Free](http://images.novusbio.com/fullsize/DOK1-[p-Tyr362]-Antibody-Western-Blot-NB100-82112-img0001.jpg)
![Western Blot DOK1 [p Tyr362] Antibody - BSA Free](http://images.novusbio.com/fullsize/DOK1-[p-Tyr362]-Antibody-Western-Blot-NB100-82112-img0004.jpg)
![Immunohistochemistry-Paraffin DOK1 [p Tyr362] Antibody - BSA Free](http://images.novusbio.com/fullsize/nb100-82112_rabbit-polyclonal-dok1-p-tyr362-antibody-103202523464515.jpg)
