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DNASE2B, also known as Deoxyribonuclease-2-beta, consists of a 41.7 kDa and a 17.8 kDa isoform and is utilized in the eye lens, salivary glands, and lungs to hydrolyze DNA in acidic conditions. Diseases and disorder such as cataract, prostatitis, and alcoholism have been researched with the protein. The protein interacts in lysosome pathways with RBL1.