DNA Ligase IV Products

Antibodies
DNA Ligase IV Antibody
DNA Ligase IV Antibody
NB110-57379
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
DNA Ligase IV Antibody
DNA Ligase IV Antibody
NBP2-16182
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
DNA Ligase IV Antibody
DNA Ligase IV Antibody
NB100-92452
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
DNA Ligase IV Overexpression ...
DNA Ligase IV Overexpression Lysat...
NBL1-12521
Applications: WB
DNA Ligase IV Overexpression ...
DNA Ligase IV Overexpression Lysat...
NBP2-10924
Applications: WB
DNA Ligase IV Overexpression ...
DNA Ligase IV Overexpression Lysat...
NBL1-12522
Applications: WB
Proteins
DNA Ligase IV Partial Recombi ...
DNA Ligase IV Partial Recombinant ...
H00003981-Q01
Species: Hu
Applications: WB, ELISA, PA
DNA Ligase IV Recombinant Pro ...
DNA Ligase IV Recombinant Protein ...
NBP1-87405PEP
Species: Hu
Applications: AC
RNAi
DNA Ligase IV RNAi
DNA Ligase IV RNAi
H00003981-R02
Species: Hu
DNA Ligase IV RNAi
DNA Ligase IV RNAi
H00003981-R01
Species: Hu

Description

LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 3981
Alternate Names
  • DNA joinase
  • sealase
  • EC 6.5.1.1
  • polynucleotide ligase
  • DNA ligase IV
  • DNA repair enzyme
  • Polydeoxyribonucleotide synthase [ATP] 4
  • DNA ligase 4
  • ligase IV, DNA, ATP-dependent

Research Areas for DNA Ligase IV

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
DNA Double Strand Break Repair
DNA Repair
Non-homologous end-joining

PTMs for DNA Ligase IV

Learn more about PTMs related to DNA Ligase IV.

Phosphorylation
Cleavage

Bioinformatics Tool for DNA Ligase IV

Discover related pathways, diseases and genes to DNA Ligase IV. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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