DMTF1 Products

Description

DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	9988 Human
Uniprot	NP_066968 Human Q9Y222 Human
Product By Gene ID	9988
Alternate Names	cyclin D binding myb-like transcription factor 1 cyclin D-binding Myb-like protein 1 cyclin-D-binding Myb-like transcription factor 1 Cyclin-D-interacting Myb-like protein 1 DMP1FLJ76054 FLJ25188 FLJ41265 hDMP1DMTF hDMTF1

Research Areas for DMTF1

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Breast Cancer