DMC1 Products

Description

DMC1 (disrupted meiotic cDNA or LIM15) is a meiosis-specific gene that encodes a nuclear protein which is essential for meiotic homologous recombination, specifically in homologous strand assimilation, and MDC1 also participates in formation of synaptonemal complex as well as double-strand breaks repair at recombination hotspots. DMC1 is a member of RecA family and in eukaryotic cells; there are two RecA homologs, RAD51 and DMC1, which promote the search for homologous DNA sequences and DNA strand exchange resulting in the formation of joint molecules. RAD51 acts both in meiotic recombinations as well as during DNA repair in mitotically dividing cells, however, DMC1 is expressed only during meiosis only. DMC1 interacts with the MND1-PSMC3IP heterodimer and with BRCA2. Dmc1-/- mice are infertile due to decreased germ cells, failing to form synaptonemal complexes and arresting at the leptotene or zygotene stage in late meiosis I. In female mice lacking Dmc1, normal oogenesis is aborted in embryos, and germ cells are depleted in the adult ovary. The phenotypes of Dmc1-/- ovaries are similar to clinical characteristics found in women with premature ovarian failure (POF), however, mutations in the coding sequence of DMC1 were shown to not to associate with POF in women.

Bioinformatics

Entrez	11144 Human 13404 Mouse
Uniprot	Q14565 Human
Product By Gene ID	11144
Alternate Names	disrupted meiotic cDNA1, yeast, homolog of DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologousrecombination (yeast) DMC1 homologue HsLim15 LIM15yeast homolog) meiosis-specific homologousrecombination meiotic recombination protein DMC1/LIM15 homolog MGC150472 MGC150473

Research Areas for DMC1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Chromatin Research
DNA Repair
Homologous Recombination
Tumor Suppressors

Related DMC1 Blog Posts

Check out the latest blog posts on DMC1.

Determining DMC1's role in Homologus Recombination The DMC1 gene encodes a 36.7 kDa nuclear protein involved in meiotic homologous recombination. This recombinase is functionally related to the yeast RAD51 and E. coli RecA genes. In contrast to RAD51, which functions in both mitotic and meiotic recomb...    Read more.

Read more DMC1 related blogs.