DLG7/HURP Products

Description

SerpinB13 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. SerpinB13 was discovered as headpin, a protein of head and neck cancers produced by keratinocytes, as hurpin, a skin specific protein downregulated by UV light, and as PI13 (proteinase inhibitor 13), a skin protein upregulated in psoriasis. As headpin, serpinB13 was reported to suppress angiogenesis in a mouse corneal neovascularization model, and to inhibit cathepsins K and L. As hurpin, serpinB13 was shown to be a selective inhibitor of cathepsin L, and to protect keratinocytes from UV induced apoptosis. Hurpin is also reported to be overexpressed in cutaneous carcinomas, although as headpin it is reportedly downregulated in head and neck cancers. Splice variants of 408, 356, 339 and 255 amino acids have also been reported, with predicted masses of 46.2, 40.3, 38.4 and 28.6 kDa respectively, and pIs of 5.69, 5.81, 5.45 and 5.83 respectively. All of the isoforms contain the reactive center loop, but it is unknown if the shorter forms are active serpins.

Bioinformatics

Entrez	9787 Human
Uniprot	NP_055565.2 Human
Product By Gene ID	9787
Alternate Names	DAP-5 Discs large homolog 7 discs, large (Drosophila) homolog-associated protein 5 disks large-associated protein 5 DLG7 Hepatoma up-regulated protein HURPDLG1 KIAA0008discs, large homolog 7 (Drosophila) large homolog 7

Research Areas for DLG7/HURP

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Core ESC-Like Genes
Stem Cell Markers