DDX3 Products

Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing of this gene generates 2 transcript variants, which are divergent in the 3'UTR.

Bioinformatics

Entrez	1654 Human
Uniprot	NP_001347.2 Human
Product By Gene ID	1654
Alternate Names	DBXCAP-Rf DDX14 DDX3DEAD/H box-3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked DEAD box protein 3, X-chromosomal DEAD box, X isoform DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 EC 3.6.1 EC 3.6.4.13 helicase like protein 2 Helicase-like protein 2 HLP2ATP-dependent RNA helicase DDX3X

Research Areas for DDX3

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Cancer
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