DAP5 Products

Description

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Bioinformatics

Entrez	13690 Mouse 1982 Human
Uniprot	NM_001418 Human NP_001409 Human P78344 Human
Product By Gene ID	1982
Alternate Names	aging-associated protein 1 DAP-5 DAP5AAG1 Death-associated protein 5 eIF4G 2 eIF-4G 2 eIF-4-gamma 2 eukaryotic translation initiation factor 4 gamma 2 eukaryotic translation initiation factor 4 gamma, 2 eukaryotic translation initiation factor 4G-like 1 FLJ41344 NAT1 P97 p97

Research Areas for DAP5

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
mTOR Pathway