DAD1 Products

Description

Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Bioinformatics

Entrez	13135 Mouse 1603 Human
Uniprot	AAH07403 Human AAH09798 Human P61803 Human
Product By Gene ID	1603
Alternate Names	DAD-1 defender against cell death 1EC 2.4.1.119 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Oligosaccharyl transferase subunit DAD1 oligosaccharyltransferase 2 homolog OST2

Research Areas for DAD1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer