CYP11B1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	1584
Alternate Names	CPN1 CYP11B1 CYPXIB1 cytochrome P450 11B1, mitochondrial cytochrome p450 XIB1 cytochrome P450, family 11, subfamily B, polypeptide 1 cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1 Cytochrome P450C11 Cytochrome P-450c11 EC 1.14.15 EC 1.14.15.4 FHICYP11B FLJ36771 P450C11DKFZp686B05283 S11BH Steroid 11-beta-hydroxylase steroid 11-beta-monooxygenase

Research Areas for CYP11B1

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Lipid and Metabolism