CRY1 Products

Antibodies
CRY1 Antibody
CRY1 Antibody
NBP1-69080
Species: Hu
Applications: WB, Simple Western, IHC, IHC-P
Host: Rabbit Polyclonal
CRY1 Antibody [Unconjugated]
CRY1 Antibody [Unconjugated]
AF3764
Species: Hu, Mu
Applications: WB, IHC, ICC
Host: Goat Polyclonal
CRY1 Antibody (4H4-1C4)
CRY1 Antibody (4H4-1C4)
H00001407-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC-P
Host: Mouse Monoclonal
Lysates
CRY1 Overexpression Lysate (N ...
CRY1 Overexpression Lysate (Native)
NBL1-09495
Applications: WB
CRY1 Overexpression Lysate (D ...
CRY1 Overexpression Lysate (Denatu...
H00001407-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human CRY1 Protei ...
Recombinant Human CRY1 Protein
H00001407-P01
Species: Hu
Applications: WB, ELISA, PA
CRY1 Blocking Peptide
CRY1 Blocking Peptide
NBP1-69080PEP
Species: Hu
Applications: AC
RNAi
CRY1 RNAi
CRY1 RNAi
H00001407-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian Cryptochrome 1 and Cryptochrome 2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and probably regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cryptochrome 1 or Cryptochrome 2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cryptochrome 1 and Cryptochrome 2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock. Cryptochromes (Cry 1 and 2) are blue, ultraviolet-A photoreceptor pigment proteins that are involved circadian rhythm regulation in plants and animals. In mammals, Cry 1 and 2 expression oscillates with respect to the daily light-dark cycle in the suprachiasmatic nucleus of the hypothalamus. These proteins localize to the cell nucleus, interact with each of the Per proteins, and assist in the translocation of Per from the cytoplasm to nucleus.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 1407
Alternate Names
  • photolyase-like cryptochrome 1
  • PHLL1cryptochrome-1
  • cryptochrome 1 (photolyase-like)

Research Areas for CRY1

Find related products by research area and learn more about each of the different research areas below.

Circadian Rhythm
Neuroscience
Vision

Bioinformatics Tool for CRY1

Discover related pathways, diseases and genes to CRY1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.