CRAT Products

Description

Carnitine acetyltransferase (CRAT) is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Different subcellular localizations of the CRAT mRNAs are thought to result from alternative splicing of the CRAT gene suggested by the divergent sequences in the 5' region of peroxisomal and mitochondrial CRAT cDNAs and the location of an intron where the sequences diverge. The alternatively splicing of this gene results in three distinct isoforms, one of which contains an N-terminial mitochondrial transit peptide, and has been shown to be located in mitochondria.

Bioinformatics

Entrez	1384 Human
Uniprot	EAW87873.1 Human NM_000755 Human NP_000746.2 Human P43155 Human
Product By Gene ID	1384
Alternate Names	Carnitine acetylase Carnitine acetyltransferaseCrAT carnitine O-acetyltransferase CAT CAT1EC 2.3.1.7 EC 2.3.1

Research Areas for CRAT

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Peroxisome Markers

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FANCD2 and DNA damage repair Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t...    Read more.

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