CPN1 Products

Description

Carboxypeptidase N (arginine carboxypeptidase or CPN) cleaves basic amino acid residues from the carboxy terminal of peptides and proteins. The enzyme plays a central role in regulating the biologic activity of peptides such as kinins and anaphylatoxins, and therefore is also known as kininase-1 and anaphylatoxin inactivator. CPN is a tetrameric complex consisting of two identical regulatory subunits (CPN reg) and two identical catalytic subunits (CPN cat). The two glycosylated CPN reg subunits protect the two CPN cat subunits and keep them in the circulation. CPN reg is a member of the leucinerich repeat family of proteins and the gene which encodes CPN reg maps to human chromosome 8p22-p23. CPN cat is a member of the regulatory B-type carboxypeptidase group and the gene which encodes CPN cat maps to human chromosome 10.

Bioinformatics

Entrez	1369 Human
Uniprot	NM_001308 Human NP_001299.1 Human P15169 Human
Product By Gene ID	1369
Alternate Names	ACBP Anaphylatoxin inactivator Arginine carboxypeptidase carboxypeptidase N polypeptide 1 50 kD Carboxypeptidase N polypeptide 1 Carboxypeptidase N small subunit carboxypeptidase N, polypeptide 1 carboxypeptidase N, polypeptide 1, 50kD CPNcarboxypeptidase N catalytic chain EC 3.4.17 EC 3.4.17.3 FLJ40792 kininase I Kininase-1 kininase-1 Lysine carboxypeptidase Plasma carboxypeptidase B SCPNcarboxypeptidase N catalytic subunit Serum carboxypeptidase N