Cortactin Products

Antibodies
Cortactin Antibody
Cortactin Antibody
NBP2-15971
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Cortactin Antibody (771716)
Cortactin Antibody (771716)
MAB6096
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Cortactin [p Tyr421] Antibody ...
Cortactin [p Tyr421] Antibody
NBP1-51464
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
Cortactin Antibody Pair
Cortactin Antibody Pair
H00002017-AP21
Species: Hu
Applications: S-ELISA
Lysates
Cortactin Overexpression Lysa ...
Cortactin Overexpression Lysate (N...
NBP2-04417
Applications: WB
Cortactin Overexpression Lysa ...
Cortactin Overexpression Lysate (N...
NBP2-10483
Applications: WB
Cortactin Overexpression Lysa ...
Cortactin Overexpression Lysate (N...
NBP2-11308
Applications: WB
Proteins
Cortactin Partial Recombinant ...
Cortactin Partial Recombinant Protein
H00002017-Q01
Species: Hu
Applications: WB, ELISA, PA
Cortactin Recombinant Protein ...
Cortactin Recombinant Protein
H00002017-P01
Species: Hu
Applications: WB, ELISA, PA
Cortactin Recombinant Protein ...
Cortactin Recombinant Protein Antigen
NBP2-38826PEP
Species: Hu
Applications: AC

Description

Immunocytochemistry reveals that in epithelial cells, the human cortactin protein is localized mainly in the cytoplasm and, to a very low extent, in protruding leading lamellae of the cell. However, in carcinoma cells that constitutively overexpress cortactin accumulates in the podosome-like adherens junctions associated with the cell-substratum contact sites. Overexpression and concomitant accumulation of the Cortactin protein in the cell-substratum contact sites might, therefore, contribute to the invasive potential of these tumor cells (1). In cells derived from breast carcinomas and squamous carcinomas of the head and neck, DNA amplification of a particular tyrosine kinase substrate region results in overexpression of cortactin. Overexpression is accompanied by a partial redistribution of cortactin from the cytoplasm into cell-matrix contact sites (2).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 2017
Alternate Names
  • 1110020L01Rik
  • Amplaxin
  • Oncogene EMS1
  • src substrate cortactin
  • ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 srcsubstrate)
  • EMS1amplaxin
  • FLJ34459
  • cortactin

Research Areas for Cortactin

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers
Phospho-Specific

Bioinformatics Tool for Cortactin

Discover related pathways, diseases and genes to Cortactin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.