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Complement Factor H Products

Antibodies
Complement Factor H Antibody ...
Complement Factor H Antibody [Unco...
AF4779
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
Complement Factor H Antibody ...
Complement Factor H Antibody [Unco...
AF4999
Species: Mu
Applications: WB, Simple Western
Host: Sheep Polyclonal
Formulation Catalog # Availability Price  
Complement Factor H Antibody ...
Complement Factor H Antibody (5563...
MAB4779
Species: Hu
Applications: WB, IP
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Antibody Pairs
Complement Factor H Antibody ...
Complement Factor H Antibody Pair ...
NBP2-79520
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Human Complement Factor H Duo ...
Human Complement Factor H DuoSet E...
DY4779
Species: Hu
Applications: ELISA
Human Complement Factor H ELI ...
Human Complement Factor H ELISA Ki...
NBP3-07016
Species: Hu
Applications: ELISA
Rat Complement Factor H ELISA ...
Rat Complement Factor H ELISA Kit ...
NBP3-18771
Species: Rt
Applications: ELISA
Lysates
Complement Factor H Overexpre ...
Complement Factor H Overexpression...
NBL1-09121
Species: Hu
Applications: WB
Proteins
Recombinant Mouse Complement ...
Recombinant Mouse Complement Facto...
4999-FH
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human Complement ...
Recombinant Human Complement Facto...
4779-FH
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Complement Factor H Recombina ...
Complement Factor H Recombinant Pr...
NBP2-38695PEP
Species: Hu
Applications: AC

Description

The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy. Factor H is mainly synthesised in the liver but also in macrophages and endothelium. It is primarily aplasma glycoprotein but is also found in platelets and there is a membrane bound form on some leukocytes. Consisting of a single polypeptide, the major form of Factor H has a molecular weight of 155kDa. There are two truncated forms, a non-glycosylated 49 kDa form and a glycosylated 39-43 kDaform. Plasma concentrations are in the range 200-600mg/L for the 155 kDa form and 1-5mg/L for thetruncated forms. Factor H is a major regulatory protein of the complement system. By binding to C3b it either displacesor prevents the binding of Bb (activated Factor B). When bound to Factor H, C3b is susceptible tocleavage by Factor 1 to yield iC3b. Factor H is released or modified following this cleavage. The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated.

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 3075
Alternate Names
  • adrenomedullin binding protein
  • age-related maculopathy susceptibility 1
  • AHUS1
  • AMBP1
  • ARMD4
  • beta-1H
  • beta-1-H-globulin
  • CFHL3
  • complement factor H
  • factor H
  • factor H-like 1
  • FH
  • FHL1
  • H factor 1 (complement)
  • H factor 1
  • H factor 2 (complement)
  • HF
  • HF1ARMS1
  • HF2
  • HUSMGC88246