Complement Factor H Products

Antibodies
Complement Factor H Antibody
Complement Factor H Antibody
AF4779
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Complement Factor H Antibody ...
Complement Factor H Antibody [Unco...
AF4999
Species: Mu
Applications: WB, Simple Western
Host: Sheep Polyclonal
Complement Factor H Antibody ...
Complement Factor H Antibody (556317)
MAB4779
Species: Hu
Applications: WB, IP
Host: Mouse Monoclonal
ELISA Kits
Lysates
Complement Factor H Overexpre ...
Complement Factor H Overexpression...
H00003075-T01
Species: Hu
Applications: WB
Complement Factor H Overexpre ...
Complement Factor H Overexpression...
NBL1-09121
Applications: WB
Proteins
Complement Factor H Recombina ...
Complement Factor H Recombinant Pr...
H00003075-P02
Species: Hu
Applications: WB, ELISA, PA
Complement Factor H Recombina ...
Complement Factor H Recombinant Pr...
H00003075-P01
Species: Hu
Applications: WB, ELISA, PA
Complement Factor H Recombina ...
Complement Factor H Recombinant Pr...
H00003075-P03
Species: Hu
Applications: WB, ELISA, PA

Description

The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy. Factor H is mainly synthesised in the liver but also in macrophages and endothelium. It is primarily aplasma glycoprotein but is also found in platelets and there is a membrane bound form on some leukocytes. Consisting of a single polypeptide, the major form of Factor H has a molecular weight of 155kDa. There are two truncated forms, a non-glycosylated 49 kDa form and a glycosylated 39-43 kDaform. Plasma concentrations are in the range 200-600mg/L for the 155 kDa form and 1-5mg/L for thetruncated forms. Factor H is a major regulatory protein of the complement system. By binding to C3b it either displacesor prevents the binding of Bb (activated Factor B). When bound to Factor H, C3b is susceptible tocleavage by Factor 1 to yield iC3b. Factor H is released or modified following this cleavage. The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 3075
Alternate Names
  • CFHL3
  • H factor 1
  • AMBP1
  • H factor 2 (complement)
  • ARMD4
  • factor H-like 1
  • AHUS1
  • factor H
  • HF2
  • beta-1H
  • HF
  • beta-1-H-globulin
  • H factor 1 (complement)
  • age-related maculopathy susceptibility 1
  • FHL1
  • adrenomedullin binding protein
  • HF1ARMS1
  • HUSMGC88246
  • FH
  • complement factor H

PTMs for Complement Factor H

Learn more about PTMs related to Complement Factor H.

Cleavage
Sulphation
Nitration
Phosphorylation
Glycosylation
Citrullination
Acetylation
Oxidation
Methylation
Deglycosylation

Bioinformatics Tool for Complement Factor H

Discover related pathways, diseases and genes to Complement Factor H. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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