Host: Sheep Polyclonal
Applications: WB, Simple Western
Host: Mouse Monoclonal
ICC/IF, IHC, IHC-P, IFHost:
Applications: WB, ELISA, PA
C9 is synthesised in the liver and monocytes, and is a plasma protein consisting of a single polypeptide chain of molecular weight 71kDa. Normal plasma concentration is 60mg/L. C9 forms part of the membrane attack complex (MAC) the cytolytic terminal complex of the complement pathways. C9 binds to the membrane associated C5b-8, binding of C9 to C5b-8 leads to the circular polymerisation of 12-18 C9 molecules. This is the basis of the hydrophilic, protein-walled, trans-membrane channel formed by the MAC, which leads to cell lysis and destruction.
Bioinformatics Tool for Complement Component C9
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