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COMMD3 (COMM Domain Containing 3) belongs to the MURR1/COMMD1 family and is expressed highly in the thymus. COMMD3 is a 22 kDA 195 amino acid protein which is involved in suppressing NF-kB. COMMD3 is known to interact with COMMD1, COMMD8, NFKB1, RELB and ZNF337.