CLCN4 Products

Antibodies
CLCN4 Antibody
CLCN4 Antibody
NBP1-84452
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CLCN4 Antibody
CLCN4 Antibody
NBP2-30066
Species: Hu
Applications: WB, ICC/IF, IHC-P
Host: Rabbit Polyclonal
CLCN4 Antibody
CLCN4 Antibody
NBP2-57670
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Lysates
CLCN4 Overexpression Lysate ( ...
CLCN4 Overexpression Lysate (Native)
NBP2-08174
Applications: WB
Proteins
CLCN4 Recombinant Protein Ant ...
CLCN4 Recombinant Protein Antigen
NBP2-57670PEP
Species: Hu
Applications: B/N, Ctrl
CLCN4 Recombinant Protein Ant ...
CLCN4 Recombinant Protein Antigen
NBP1-84452PEP
Species: Hu
Applications: AC
RNAi
CLCN4 RNAi
CLCN4 RNAi
H00001183-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 1183
Alternate Names
  • ClC-4
  • H(+)/Cl(-) exchange transporter 4
  • Chloride transporter ClC-4
  • Chloride channel protein 4
  • MGC163150
  • CLC4
  • ClC-4A
  • chloride channel 4

PTMs for CLCN4

Learn more about PTMs related to CLCN4.

Phosphorylation
Oxidation

Bioinformatics Tool for CLCN4

Discover related pathways, diseases and genes to CLCN4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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