Claudin-7 Products

Description

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. mRNA studies indicate that claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis. The gene encoding human claudin-7 maps to chromosome 17p13.

Bioinformatics

Entrez	1366 Human 65132 Rat
Uniprot	NM_001307 Human NP_001298 Human O95471 Human
Product By Gene ID	1366
Alternate Names	CEPTRL2 claudin 7 claudin-1 claudin-7 CLDN-7 clostridium perfringens enterotoxin receptor-like 2 CPETRL2

Diseases related to Claudin-7

Discover more about diseases related to Claudin-7.

Neoplasms
Carcinoma
Malignant Neoplasms
Tissue Adhesions
Neoplasm Metastasis
Adenocarcinoma
Malignant Squamous Cell Neoplasm
Malignant Paraganglionic Neoplasm
Cell Invasion
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Mammary Neoplasms
Tumor Progression
Cell Transformation, Neoplastic
Lymphatic Metastasis
Kidney Neoplasm
Ovarian Neoplasm
Renal Cell Carcinoma
Colorectal Cancer
Colorectal Neoplasms

Pathways for Claudin-7

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Localization
Transport
Cell Adhesion
Cell-cell Adhesion
Methylation
Pathogenesis
Cell Migration
Gene Silencing
Aging
Reverse Transcription
Cell Cycle
Cell Differentiation
Cell Proliferation
Ion Transport
Cell Growth
Keratinization
Epithelial Cell-cell Adhesion
Tight Junction Assembly
Water Transport
Cell Motility

Research Areas for Claudin-7

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Breast Cancer
Cancer

PTMs for Claudin-7

Learn more about PTMs related to Claudin-7.

Phosphorylation
Methylation
Demethylation
Reduction

Bioinformatics Tool for Claudin-7

Discover related pathways, diseases and genes to Claudin-7. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.