CIDEA Products

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD (1-4). DFF45 related proteins CIDEA and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified (5). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (5,6). Expression of CIDEA induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDEA is expressed in many tissues.

Bioinformatics

Entrez	1149 Human
Uniprot	O60543 Human
Product By Gene ID	1149
Alternate Names	cell death activator CIDE-A cell death-inducing DFFA-like effector aCIDE-A CIDEA

Research Areas for CIDEA

Find related products by research area and learn more about each of the different research areas below.

Apoptosis