CHTF8 Products

Description

CHTF8 encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 4 encode the same isoform (A).

Bioinformatics

Entrez	54921 Human
Uniprot	NM_001039690 Human NP_001035236 Human
Product By Gene ID	54921
Alternate Names	chromosome transmission fidelity protein 8 homolog CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) CTF8hCTF8 Decreased expression in renal and prostate cancer protein DERPCchromosome transmission fidelity factor 8 homolog FLJ20400