CHMP4B Products

Description

Component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. in the escrt-iii complex, it probably serves as an acceptor for escrt-i complex on endosomal membranes. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins, via the association of chmp4 proteins with pdcd6ip/aip1, a protein directly recruited by hiv-1 p6 protein that functions at sites of viral gag assembly and budding.

Bioinformatics

Entrez	128866 Human 312254 Rat 75608 Mouse
Uniprot	NP_789782 Human Q9H444 Human
Product By Gene ID	128866
Alternate Names	C20orf178 charged multivesicular body protein 4b CHMP4A CHMP4b chromatin modifying protein 4B Chromatin-modifying protein 4b chromosome 20 open reading frame 178 dJ553F4.4 hSnf7-2 hVps32-2 SHAX1 Shax1 SNF7 homolog associated with Alix 1 Snf7 homologue associated with Alix 1 SNF7 SNF7-2CTPP3 Vacuolar protein sorting-associated protein 32-2 vacuolar protein-sorting-associated protein 32-2 Vps32-2 VPS32B