Centaurin beta 2 Products

Description

Centaurin beta 1 and Centaurin beta 2 are recruited to platelet-derived growth factor-induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, and overexpression inhibited ruffle formation. In vitro, Centaurin beta 1 and Centaurin beta 2 preferred ARF6 as substrate rather than ARF1 or ARF5, and the GAP activity of both Centaurins was dependent upon phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). The isolated PH domain of mouse Centaurin beta 2 exhibits moderate affinity for PtdIns(3,5)P2, but it does not bind any other phosphoinositides tested, including PtdIns(4,5)P2. Mutation of a highly conserved arginine in both Centaurins result in lack of ARF-GAP activity. Overexpression in HeLa cells of either Centaurin blocks the formation of ARF6-dependent protrusions. Both Centaurins are also recruited to peripheral, tubular membranes, where activation of ARF6 occurs and allows membrane recycling back to the plasma membrane.

Bioinformatics

Product By Gene ID	23527
Alternate Names	Arf GAP with coiled coil, ANK repeat and PH domains 2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 centaurin, beta 2 Centaurin-beta-2 CENTB2centaurin-beta-2 CNT-B2 KIAA0041arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Research Areas for Centaurin beta 2

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Signal Transduction