Centaurin beta 2 Products

Antibodies
Centaurin beta 2 Antibody
Centaurin beta 2 Antibody
NBP2-24528
Species: Hu, Mu, Rt, Ca, Eq, Pm
Applications: WB, IHC
Host: Rabbit Polyclonal
Centaurin beta 2 Antibody
Centaurin beta 2 Antibody
NB100-1321
Species: Hu, Mu, Rt, Po, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Centaurin beta 2 Antibody - B ...
Centaurin beta 2 Antibody - BSA Free
NBP1-84544
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
Lysates
Centaurin beta 2 Overexpressi ...
Centaurin beta 2 Overexpression Ly...
NBL1-09095
Species: Hu
Applications: WB
Proteins
Recombinant Human Centaurin b ...
Recombinant Human Centaurin beta 2...
H00023527-P01
Species: Hu
Applications: WB, ELISA, MA, AP
Centaurin beta 2 Recombinant ...
Centaurin beta 2 Recombinant Prote...
NBP1-84543PEP
Species: Hu
Applications: AC
Centaurin beta 2 Recombinant ...
Centaurin beta 2 Recombinant Prote...
NBP1-84544PEP
Species: Hu
Applications: AC

Description

Centaurin beta 1 and Centaurin beta 2 are recruited to platelet-derived growth factor-induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, and overexpression inhibited ruffle formation. In vitro, Centaurin beta 1 and Centaurin beta 2 preferred ARF6 as substrate rather than ARF1 or ARF5, and the GAP activity of both Centaurins was dependent upon phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). The isolated PH domain of mouse Centaurin beta 2 exhibits moderate affinity for PtdIns(3,5)P2, but it does not bind any other phosphoinositides tested, including PtdIns(4,5)P2. Mutation of a highly conserved arginine in both Centaurins result in lack of ARF-GAP activity. Overexpression in HeLa cells of either Centaurin blocks the formation of ARF6-dependent protrusions. Both Centaurins are also recruited to peripheral, tubular membranes, where activation of ARF6 occurs and allows membrane recycling back to the plasma membrane.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 23527
Alternate Names
  • Arf GAP with coiled coil, ANK repeat and PH domains 2
  • ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  • centaurin, beta 2
  • Centaurin-beta-2
  • CENTB2centaurin-beta-2
  • CNT-B2
  • Cnt-b2
  • KIAA0041arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2