Centaurin beta 2 Products

Antibodies
Centaurin beta 2 Antibody
Centaurin beta 2 Antibody
NBP2-24528
Species: Hu, Mu, Rt, Ca, Eq, Pm
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Centaurin beta 2 Antibody
Centaurin beta 2 Antibody
NB100-1321
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
Centaurin beta 2 Antibody
Centaurin beta 2 Antibody
NBP1-84543
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
Centaurin beta 2 Antibody Pai ...
Centaurin beta 2 Antibody Pair
H00023527-PW1
Species: Hu
Applications: WB, IP
Lysates
Centaurin beta 2 Overexpressi ...
Centaurin beta 2 Overexpression Ly...
H00023527-T01
Species: Hu
Applications: WB
Centaurin beta 2 Overexpressi ...
Centaurin beta 2 Overexpression Ly...
NBL1-09095
Applications: WB
Proteins
Centaurin beta 2 Partial Reco ...
Centaurin beta 2 Partial Recombina...
H00023527-Q01
Species: Hu
Applications: WB, ELISA, PA
Centaurin beta 2 Recombinant ...
Centaurin beta 2 Recombinant Protein
H00023527-P01
Species: Hu
Applications: WB, ELISA, PA
Centaurin beta 2 Recombinant ...
Centaurin beta 2 Recombinant Prote...
NBP1-84543PEP
Species: Hu
Applications: AC
RNAi
Centaurin beta 2 RNAi
Centaurin beta 2 RNAi
H00023527-R01
Species: Hu

Description

Centaurin beta 1 and Centaurin beta 2 are recruited to platelet-derived growth factor-induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, and overexpression inhibited ruffle formation. In vitro, Centaurin beta 1 and Centaurin beta 2 preferred ARF6 as substrate rather than ARF1 or ARF5, and the GAP activity of both Centaurins was dependent upon phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). The isolated PH domain of mouse Centaurin beta 2 exhibits moderate affinity for PtdIns(3,5)P2, but it does not bind any other phosphoinositides tested, including PtdIns(4,5)P2. Mutation of a highly conserved arginine in both Centaurins result in lack of ARF-GAP activity. Overexpression in HeLa cells of either Centaurin blocks the formation of ARF6-dependent protrusions. Both Centaurins are also recruited to peripheral, tubular membranes, where activation of ARF6 occurs and allows membrane recycling back to the plasma membrane.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 23527
Alternate Names
  • Cnt-b2
  • centaurin, beta 2
  • Centaurin-beta-2
  • CNT-B2
  • CENTB2centaurin-beta-2
  • KIAA0041arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
  • Arf GAP with coiled coil, ANK repeat and PH domains 2
  • ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Diseases related to Centaurin beta 2

Discover more about diseases related to Centaurin beta 2.

Vaccinia
Cowpox
Tissue Adhesions

Pathways for Centaurin beta 2

View related products by pathway and learn more about each of the pathways below.

Transport
Phagocytosis
Endocytic Recycling
Cell Migration
Phagosome Formation
Cell Motility
Localization
Viral Replication
Rna Interference
Cytokinesis
Protein Adp-ribosylation

PTMs for Centaurin beta 2

Learn more about PTMs related to Centaurin beta 2.

Ribosylation

Bioinformatics Tool for Centaurin beta 2

Discover related pathways, diseases and genes to Centaurin beta 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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