Cdx1 Products

Description

The transcription factors Cdx1 and Cdx2 are members of the caudal-related homeobox gene family based on their homology to the factor caudal in Drosophila melanogaster. The caudal homeobox factor is required for anterior-posterior regional identity and axial patterning in Drosophila. During mouse development, the expression of Cdx1 and Cdx2 can be divided into two stages that likely reflect distinct roles. During early development, these two factors are expressed in a Hox-like manner in the three germ layers and appear to have overlapping functions in anterior-posterior patterning and posterior axis elongation. The second stage of Cdx1 and Cdx2 expression, from late development into adulthood, is characterized by the loss of expression almost everywhere but the epithelium of small intestine and colon. Putative intestine-specific enhancers upstream of the CDX1 gene have been identified that may orchestrate the switch in expression patterns for that gene. As might be expected from this pattern of expression, a wide variety of in vivo and in vitro studies have suggested that these two factors are important in controlling epithelial cell differentiation, proliferation, and function in the intestine.

Bioinformatics

Entrez	1044 Human 12590 Mouse
Uniprot	NP_001795 Human P47902 Human NM_001804 Human P18111 Mouse
Product By Gene ID	1044
Alternate Names	homeobox protein CDX-1 MGC116915 caudal-type homeobox protein CDX1 Caudal-type homeobox protein 1 caudal type homeobox transcription factor 1 caudal type homeo box transcription factor 1 caudal type homeobox 1

Diseases related to Cdx1

Discover more about diseases related to Cdx1.

Malignant Neoplasms
Neoplasms
Metaplasia
Carcinoma
Adenocarcinoma
Colorectal Neoplasms
Colonic Neoplasms
Colorectal Cancer
Malignant Tumor Of Colon
Stomach Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Stomach
Carcinogenesis
Precancerous Conditions
Barrett Esophagus
Gastroesophageal Reflux Disease
Adenoma
Inflammation
Gastritis

Pathways for Cdx1

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Cell Proliferation
Pathogenesis
Methylation
Cell Differentiation
Gastrulation
Localization
Dna Methylation
Cell Growth
Cell-cell Adhesion
Epithelial Cell Proliferation
Cell Adhesion
Cell Cycle
Transdifferentiation
Demethylation
Cell Migration
Segmentation
Oncogenesis
Somitogenesis
Hypersensitivity
Endoderm Development

Research Areas for Cdx1

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Chromatin Modifiers
Epigenetics

PTMs for Cdx1

Learn more about PTMs related to Cdx1.

Methylation
Phosphorylation
Demethylation
Reduction
Acetylation

Bioinformatics Tool for Cdx1

Discover related pathways, diseases and genes to Cdx1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.